Moreover, the nonspecific reactivity in the hantavirus ELISA is compatible with polyclonal B cell activation resulting from CMV, EBV, Plasmodium spp., or hantavirus infections (45) and emphasizes the value of confirming IgM/IgG ELISA results, ideally by neutralization tests (NTs) for IgG (15,16). This evidence concerns the gene CD40LG and hantavirus infectious disease.