MAPT and Alzheimer disease: However, Braak et al. have reported that AD-like tau pathology is present in the transentorhinal region as early as at 20 years of age—and above the age of 60 years, most people have AD-like tau pathology in the transentorhinal region, entorhinal region proper, and hippocampal formation, independent of their underlying diseases (Braak et al., 2011).