Given that tau propagation and accumulation can be detected in WT mice after human PART tau injection (Ferrer et al., 2020), we speculate that accumulation and propagation of PART tau would be accelerated by the presence of amyloid plaques as well as by the humanization of tau protein, as shown in a previous study with AD tau (Saito et al., 2019). Here, MAPT is linked to Alzheimer disease.