CHI3L1 and glioblastoma: We hence first examined a potential signature of chemoresistance among the genes up-regulated upon ADD3 OE (Fig 6A) and found CHI3L1 as a key molecule involved in TMZ and radioresistance in GBM cell lines (Akiyama et al, 2014; Shao et al, 2014; Zhao et al, 2020).