Previous experimental evidence in support of talin’s role in APP processing includes the following findings: (i) APP immunoreactivity is co-localized with talin immunoreactivity in primary rat neuronal cultures, including hippocampal, cortical and cerebellar tissues [35]; (ii) talin2 has been implicated in AD [36]; and (iii) talin has been linked to APP both in mouse models of AD [59] and in platelets of patients with AD [60]. The gene discussed is APP; the disease is Alzheimer disease.