,8,9,10,11,12,13,14,15 We demonstrate that a high abundance of TILs co-expressing PD1 with LAG3, TIGIT, or TIM3 within the tumor microenvironment predicts poorer ORRs, PFS, and OS in patients with NSCLC treated with ICIs, regardless of PD-L1 status. Here, CD274 is linked to neoplasm.