To investigate the impact of T cell distribution within the tumor microenvironment on patient outcomes, we performed spatial analysis, measuring distances between “Competent” CD8+ (CD8+/PD1−) and CD8+/Exh (CD8+/PD1+ ± LAG3/TIGIT/TIM3+) cells in relation to tumor (CK7+) cells. Here, LAG3 is linked to neoplasm.