More recently, circular RNA circ_SETD2, produced by reverse splicing of SETD2 gene, has been shown to repress breast cancer progression through the regulation of SCUBE2 (signal peptide-CUB-epidermal growth factor-like domain-containing 2) via competitively binding to miR-155-5p [99]. The gene discussed is SETD2; the disease is breast carcinoma.