SETD2 and B-cell chronic lymphocytic leukemia: Defects in SETD2 have been also detected in many lymphoid malignancies such as precursor B-cell lymphoblastic leukemia, early-T-precursor lymphoblastic leukemia, diffuse large B-cell lymphoma, chronic lymphoblastic leukemia, small lymphocytic lymphoma [66] and even in mast cell leukemia [67].