In a same way, the SETD2-Nf1 fusion gene (Fig. 5), identified in a paediatric spindle cell tumour with the chromosomal translocation t(3;17)(p21;q12), results in deletion of the SETD2 SRI domain and a decrease in H3K36me3 level [37]. The gene discussed is NF1; the disease is spindle cell neoplasm.