SETD2 and acute myeloid leukemia: A recent study in mice harboring two loss-of-function (LOF) SETD2 mutation alleles (SETD2F2478L and SETD2Ex6-KO) revealed that SETD2 mutations lead to a decreased of S and G2/M checkpoint activity on AML cells hence enabling the cells to escape from massive DNA damage-induced S-phase cell cycle arrest and cell death [102].