These observations are in line with the results of Mar et al., that indicate that in isogenic leukemia cell lines and in murine leukemia SETD2 mutations led to resistance to DNA-damaging agents, cytarabine (Cytarabine), 6-thioguanine, doxorubicin, and etoposide (Etoposide), but not to a non–DNA damaging agent, L-asparaginase [103,104]. The gene discussed is ASPG; the disease is leukemia.