PIM1 and Airway obstruction: Furthermore, this miRNA has been shown to target CALR and PIM1, which are involved in MC differentiation and recruitment, respectively [45–47], as well as IL-13, which exacerbates the hyper-responsiveness and airway obstruction caused by MCs in asthma patients [48], all of which are upregulated in MC’s in response to IL-33 and a decrease in miR-6883-5p.