The analysis revealed that the AUC values for HMGA1, HMGB2, HMGB3, HMGN1, HMGN2, and HMGN4 were all greater than 0.7 (S1A and S1B Fig), demonstrating that these six HMGs genes have good sensitivity and specificity in diagnosing HCC. The gene discussed is HMGN2; the disease is hepatocellular carcinoma.