The analysis revealed that the AUC values for HMGA1, HMGB2, HMGB3, HMGN1, HMGN2, and HMGN4 were all greater than 0.7 (S1A and S1B Fig), demonstrating that these six HMGs genes have good sensitivity and specificity in diagnosing HCC. Here, HMGA1 is linked to hepatocellular carcinoma.