Therefore, the influence of the ACE I/D and AGTR1 polymorphisms on the progression of Chagas’ heart disease could have been masked using cardioprotective drugs, as ACEi/ARB were also prescribed to patients staged as B1 and A. As in other heart diseases, the treatment of HF secondary to Chagas cardiomyopathy is based on the combination of three types of drugs: diuretics, ACEi/ARB, and adrenergic blockers [10,47]. The gene discussed is AGTR1; the disease is heart disorder.