Further, this cross-sectional observational study supports that ACE D carriers show a more prominent systemic inflammatory profile than II carriers, thus opening an avenue to be challenged regarding the progression of Chagas’ heart disease and other clinical traits, such as stroke, that deserves a prospective study in this cohort as well as replication study in other populations, aiming, particularly, the identification of ACE D carriers. The gene discussed is ACE; the disease is Stroke.