We pinpointed thirteen genes initially associated with aging and AD, including five novel genes (RP11-557H15.4, CHKA, SNHG5, DCAF6, INPP4B) related to age and AD in humans, and eight novel genes (Lyz2, Gpr165, Upk1b, Cc16, CD9, Lilrb4a, H2-Ab1, Itgax) in mice. Here, ITGAX is linked to Alzheimer disease.