In summary, pseudotime analyses of AD-related microglial cells in humans and mice revealed similarities and differences.(1) Similarities: Cell_APOE/Apoe densities had similar trends in both species, and the Fc gamma R-mediated phagocytosis pathway was shared between humans and mice.(2) Differences: Cell_CX3CR1/Cx3cr1 densities showed different trends between humans and mice. This evidence concerns the gene APOE and Alzheimer disease.