NFKB1 and obesity due to melanocortin 4 receptor deficiency: All in all, our current results provide preliminary evidence that miR-130b-MV significantly increased hepatic inflammation under obesity state, which was partly due to GR-mediated immunosuppression and NF-κB activation, suggesting a novel mechanism underlying the obesity-induced hepatic inflammation and injury as well as a novel strategy in preventive and therapeutic approaches for metabolic disorders.