Very recently, Putira Sacuena et al., 2024, [46] identified the ACE rs4646994 polymorphism in 263 individuals from different indigenous ethnicities in the Amazon region aged between 10 and 95 years, with the aim of identifying the genetic factors that, in their study population, could contribute to the low frequency of SARS-CoV-2 infection detected in the Amazon during the COVID-19 pandemic. Here, ACE is linked to COVID-19.