In contrast, only three out of 11 patients with HRDneg samples who experienced partial response, or complete response as best response had a concurrent pathogenic variant other than in TP53, and none of these variants (CCNE1 amplification, frameshift mutation in NRG1, and missense mutation in FGFR2) could explain the paradoxical radiologic tumor shrinkage. The gene discussed is FGFR2; the disease is neoplasm.