CD40LG and hepatitis A virus infection: Passive laboratory-based surveillance data collected between 2017 and 2020 show a national hepatitis A incidence rate (based on IgM anti-HAV positivity) of 6–10 cases/100,000 per year among 1–9-year-olds, with the highest incidence rates recorded in the Western Cape province (7–10/100,000) [15].