After both natural infection and complete mRNA vaccination, we detected lower frequencies of early differentiated central memory (TCM) T cell subsets (defined as CD45RA−, CCR7+ and CD27+) as well as higher frequencies of effector memory 1 T cells (TEM1) (defined as CD45RA−, CCR7− and CD27+) in MM patients. This evidence concerns the gene CCR7 and infection.