ACE2 and infection: This includes a lack of data on the infection and replication of authentic virus in primary cells and in vivo models, the use of transient overexpression models to study ACE2 usage of SARS-CoV-2 S proteins, and the absence of data on potential differences in SARS-CoV-2 lineage-specific neutralization by antibodies induced upon vaccination with updated JN.1- or KP.2-based mRNA vaccines.