Significant improvement in the encapsulation efficiency of curcumin by 81 ± 1.43% and drug loading capacity by 19.32 ± 0.6%.In vivo mouse model showed the anticancer activity of gold NP-based curcumin delivery with reduced tumor growth and volume.Increased IFN-γ (nearly 2-fold) and decreased IL-4 levels (nearly 4-fold). This evidence concerns the gene IFNG and neoplasm.