The neuroprotective properties of Resv have been widely studied in mammalian models, including rodents: Resv’s ability to modulate autophagy, reduce oxidative stress, and activate pathways such as SIRT1 has been documented across various mammalian models of neuro-degenerative diseases, such as Alzheimer’s and Parkinson’s diseases. This evidence concerns the gene SIRT1 and Parkinson disease.