NLRP3 and obesity due to melanocortin 4 receptor deficiency: In addition, this process triggers a cascade of events, which inhibits the following: (1) locomotion and diapedesis of leukocytes; (2) cytokine production; (3)formation of reactive oxygen species (ROS); and (4) formation of the NLRP3 inflammasome, a key component in the chronic inflammation observed in obesity [20,21] (Figure 2).