Notably, the association of SHBG and sexual hormone fluctuations with alcohol addiction is also sustained by heritable traits as reported in a recent GWAS study where SHBG showed a positive genetic correlation with alcohol consumption after adjustment for BMI, thus suggesting that sex-specific heritable predispositions for higher or lower levels of steroid sex hormones and their binding proteins contribute to alcohol-use behaviors and disorders in some contexts [102]. This evidence concerns the gene SHBG and alcohol dependence.