NLRP3 and Hepatitis: In addition, under an alcohol binge, the NLRP3 inflammasome activation is also followed by an increase in circulating extracellular apoptosis-associated speck-like protein containing a caspase recruitment domain (ex-ASC) specks and hepatic ASC aggregates which in turn trigger IL-1β release in alcohol-naïve monocytes in mouse models, a mechanism prevented by the NLRP3 inhibitor, thus indicating that these factors are involved in the propagation of systemic and liver inflammation in AH [92].