TCN1 and cholestasis: Lambert et al. reported that ALD patients show significantly higher levels of total plasma VB12, haptocorrin (HC)-bound VB12, and corrinoid analogs compared to controls; they also noted a positive correlation between cholestasis markers, such as serum alkaline phosphatase, and elevated levels of HC-bound VB12 and corrinoids in cirrhotic patients, suggesting that cholestasis contributes to the altered VB12 dynamics observed in ALD [37].