In patients with Gaucher disease type 1, osteopontin positively correlated to bone disease domain (r = 0.28, p-value = 0.001) and GD-DS3 (r = 0.37, p-value < 0.001), while MMP-2 was positively correlated to GD-DS3 (r = 0.20, p-value = 0.022) but not to bone disease. This evidence concerns the gene SPP1 and Gaucher disease type 1.