ACE and osteonecrosis: Plasma biochemistry was similar across groups, except for a significantly increased platelet count and angiotensin-converting enzyme levels in patients with a prior history of osteonecrosis (median 194 [IQR 160–252]; median 51 [IQR 38–80], respectively) than those free from osteonecrosis (median 178 109/L [IQR 145–219], p = 0.043; median 40 109/L [IQR 25–58], p = 0.040; details in Table 2).