Thus, taking all the aforementioned into consideration, we conducted a study aimed at investigating the serum profile of myokines (myonectin, myostatin, and irisin) in patients with MASLD and HTN, and evaluated the correlations between serum concentrations of myokines, biochemical parameters indicative of metabolic health, liver disease severity, and HTN grade in this patient category. The gene discussed is FNDC5; the disease is liver disorder.