Besides the fact that increased physical activity remains to this day the only effective way to prevent the development and slow the progression of MASLD—and that muscle contraction is precisely the process by which myokines such as myonectin and irisin are produced by muscles [21,22]—it is possible that at least some of the beneficial effects of physical activity on metabolism and the course of MASLD are associated with the action of myokines. This evidence concerns the gene FNDC5 and metabolic dysfunction-associated steatotic liver disease.