Thus, taking all the aforementioned into consideration, we conducted a study aimed at investigating the serum profile of myokines (myonectin, myostatin, and irisin) in patients with MASLD and HTN, and evaluated the correlations between serum concentrations of myokines, biochemical parameters indicative of metabolic health, liver disease severity, and HTN grade in this patient category. This evidence concerns the gene MSTN and hypertensive disorder.