There were strong direct correlations between WMI and plasma IL-1β levels in the IRA (r = 0.894; p = 0.0014), peripheral artery (r = 0.704; p = 0.008) and vein on day 1 (r = 0.763; p = 0.024) in patients with CS. The gene discussed is IL1B; the disease is Cowden syndrome 1.