The ZMYM2-FGFR1 fusion protein contains the zinc finger domain of ZMYM2, mediating the constitutive activation of FGFR1 and causing sustained activation of the Notch pathway, which is closely related to the development of T-cell acute lymphoblastic leukemia (T-ALL) [30]. The gene discussed is ZMYM2; the disease is T-cell acute lymphoblastic leukemia.