In many other perinatally or prenatally lethal mutant mouse lines, half of the embryos survive until E14.5, including some in which the cause of death is intracerebral hemorrhage by mutations that affect endothelial cell function such as Fli1 [41] and Erg [13] transcription factors, and integrin-αvβ8 adhesion molecules [27,42]. The gene discussed is FLI1; the disease is intracerebral hemorrhage.