TGFA and colorectal cancer: Additionally, it has been demonstrated that TGFα interaction with EGFR promotes VEGF expression, and that higher serum levels of VEGF are linked to a shorter disease-free survival in patients with colorectal cancer; this could be because VEGF-mediated angiogenesis occurs through the migration, differentiation, and proliferation of vascular endothelial cells [43,44,45].