Hypoxia, common in the chondrosarcoma TME, activates hypoxia-inducible factors (HIF-1α and HIF-2α), which further promote metastasis by triggering pathways involved in cancer cell dormancy, angiogenesis, and ECM remodeling, as well as contributing to chemoresistance through cancer stem cell survival [17]. This evidence concerns the gene EPAS1 and cancer.