Biologically active compounds in natural products derived from plants, aquatic organisms, and microbes have become major resources for the development of cancer chemopreventive or chemotherapeutic agents by effectively inhibiting cell proliferation, regulating the cell cycle, and interfering with various oncogenic signaling pathways involving phosphoinositol-3 kinases/protein kinase B (PI3K/AKT), mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK), Wingless and Int-1 (Wnt)/β-catenin, and matrix metalloproteases [A]. Here, AKT1 is linked to cancer.