HIF1A and central nervous system cancer: In this study, it was shown that the combination treatment of M4N with A4N markedly reduced the expression of the SP1, MYC, and HIF1A proteins as well as various cancer stem cell- and EM transition-related proteins in the LN229 and U87MG glioma cell lines and greatly induced cell death in both of these cell lines (Figure 2I,III).