We also examined whether the suppression of SP1, MYC, and HIF1A could reduce the expression of various stem cell-related genes that played important roles in cancer development, which suggested the possibility that M4N, as an SP1/HIF inhibitor that lacks activity to inhibit MYC, might induce anticancer activity via its effect on suppressing the expression of stem cell-related genes to some extent [15]. This evidence concerns the gene HIF1A and cancer.