In head and neck cancers, recent descriptions include neoplasms with deficiencies in certain subunits of the SWI/SNF complex, such as malignant rhabdoid tumors, head and neck epithelioid sarcoma, SMARCB1-deficient sinonasal carcinoma, SMARCB1-deficient sinonasal adenocarcinoma, SMARCA4-deficient sinonasal carcinoma, and SMARCA4-deficient sinonasal teratocarcinosarcoma [6]. Here, SMARCA4 is linked to nasal cavity and paranasal sinus carcinoma.