Deficiency in the SMARCA4 subunit has been described in rare malignant neoplasms with poor prognosis, such as small cell carcinoma of the ovary, hypercalcemia type (SCCOHT), some thoracic carcinomas, gastrointestinal and genitourinary tract carcinomas, and non-small-cell lung carcinoma [33]. The gene discussed is SMARCA4; the disease is hypercalcemia disease.