Flow cytometry analysis revealed that the apoptosis rate and erythroid differentiation expression rate in the PTPN6 knockdown SKM-1 cell line were reduced, and the expression levels of the proinflammatory factors IL-6 and IL-8 increased, while the expression levels of the inhibitor factor IL-4 decreased, providing direction for our further exploration of MDS. This evidence concerns the gene IL6 and myelodysplastic syndrome.