Given the significant role of PTPN6 mutations in MDS, but with no existing studies showing a correlation between PTPN6 knockdown in the MDS cell line SKM-1 and apoptosis, erythroid differentiation, and inflammations, we constructed a stable H_PTPN6-shRNA SKM-1 cell line by infecting SKM-1 cells with recombinant lentiviral plasmids and packaging plasmids. Here, FUT1 is linked to myelodysplastic syndrome.