Schizandrin II and Schizandrin A from Schisandrae fructus were shown to interact with target proteins, including IL-4, IL-6, STAT3, and NFKBIA, which are involved in psoriasis-related pathways such as tumor necrosis factor-mediated signaling, cytoplasmic sequestration of NF-κB, and cellular response to lipopolysaccharide. This evidence concerns the gene NFKBIA and psoriasis.