Among them, CCL5-CCR5, CCL4-CCR5, CCL6-CCR2, and CXCL2-CXCL2R increased after infection, with the CCL5-CCR5 signaling pathway between macrophages and T-cells predominating at 6 w post-infection and the CCL6-CCR2 signaling pathway between macrophages at 10 w. The gene discussed is CCR5; the disease is infection.