Attur et al. examined the effects of single nucleotide variants (SNVs) in the IL1RN gene, which encodes the anti-inflammatory interleukin-1 receptor antagonist (IL-1Ra), on cytokine release syndrome (CRS) and mortality in patients with acute SARS-CoV-2 infection [121]. The gene discussed is IL1RN; the disease is congenital rubella syndrome.