The IL1RN haplotype CTA and the C/C variant of rs419598 were associated with reduced CRS and mortality in men with acute SARS-CoV-2 infection, according to research by Attur et al. This suggests that the IL1RN pathway plays a role in determining the severity of COVID-19 by influencing natural anti-inflammatory mechanisms [121]. Here, IL1RN is linked to COVID-19.