However, to the best of our knowledge, changes in serum chloride concentrations and sodium-to-chloride ratio, along with their associations with N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) concentration during 6 and 12 months of follow-up in patients in whom SGLT2is are initiated as part of HF therapy, and their impact on prognosis, are unknown. Here, NPPB is linked to hydrops fetalis.