These receptors can recognize sialic acid structures on tumor surfaces, activating downstream Syk-Neutrophil cytosolic factor 1 (P47phox) signaling pathways and the arachidonic acid (AA)-12 and 15-lipoxygenase (HETE)-peroxisome proliferator-activated receptor γ (PPARγ) signaling axis. The gene discussed is NCF1; the disease is neoplasm.