Myeloma cells are known to evade the immune system by several mechanisms including reduced HLA expression, reduced tumor antigens, increased expression of T-cell inhibitory ligands such as programmed cell death ligand-1 (PD-L1) and PD-L2, recruitment of Tregs, myeloid-derived suppressor cells (MDSCs), and dendritic cells [74]. The gene discussed is CD274; the disease is plasma cell myeloma.