For patients with a history of HER2+ metastatic breast cancer who are diagnosed with brain metastases, multidisciplinary care with representation from radiology, radiation oncology, neurosurgery, medical oncology, and supportive care is the standard of care, with the multidisciplinary team (MDT) providing recommendations on sequencing of local and systemic therapies (REAL Alliance Expert opinion). The gene discussed is ERBB2; the disease is breast cancer.