CTLA4 and prostate neoplasm: Low levels of SOD3 expression have been observed in lung and prostate tumor tissue [18,47], while high expression of SOD3 in lung tumor tissue was associated with a low probability of survival due to the infiltration of the proteins PDCD1 (programmed cell death 1) and CTLA4 (lymphocyte-associated protein 4 T cytotoxic), which play a role in the immune system [47].