Experimental studies have shown that myogenic response is enhanced, being an adaptive mechanism in HTN, and this process is partly mediated by the increase in intracellular Ca2+ in vascular smooth muscle cells (VSMCs) through upregulation of the 20-hydroxyeicosatetraenoic-acid (20-HETE)–short transient receptor potential channel 6 (TRPC6) pathway. The gene discussed is TRPC6; the disease is hypertensive disorder.