For example, ZFP36 has tumour‐suppressive properties that are directly related to its ability to post‐transcriptionally regulate oncogenic mRNAs, including NOTCH1, MYC, BCL‐2, and COX‐2.[24, 25, 26] ZFP36 can also complement the function of tumour suppressors such as p53 and LATS2.[27, 28] In this study, we found that Zfp36SMKO mice developed a phenotype with decreased blood pressure under both physiological and pathological conditions by regulating the contraction of VSMCs, which enhances our understanding of the functions of ZFP36. This evidence concerns the gene NOTCH1 and neoplasm.