PPARGC1A and neoplasm: To check whether the increased OXPHOS caused by PGC-1α overexpression in cell lines would translate to higher bioenergetics in tumors, ASCL1, or POU2F3/ASCL2 cell lines with and without PGC-1α overexpression were xenografted into immunocompromised mice for tumor initiation and subsequent microPET/CT imaging.