The analysis showed that 6 proteins, SHBG, APOD, IGFBP2, IGFBP6, cartilage oligomeric matrix protein (COMP), and platelet factor 4 variant 1 (PF4V1), were differentially expressed when both T2D-progressors and nonprogressors were healthy (Figure 4C). The gene discussed is SHBG; the disease is type 2 diabetes mellitus.