Additionally, we ensured the robustness of our method by a tight correlation between protein quantity values measured by LC-MS/MS and ELISA of CRP (ρ = 0.98) and adiponectin (ρ = 0.63), which are established inflammatory and antiinflammatory markers in T2D (23, 24) (Supplemental Figure 1E). Here, CRP is linked to type 2 diabetes mellitus.