PON3 and type 2 diabetes mellitus: PON3 showed a greater tendency to decline over the 4 years between the 6- and 10-year visits in the T2D-progressor group (paired adjusted P [Padj.] ≤ 0.01 and log2[10 years/6 years]: –0.42) compared with the nonprogressor group (paired Padj. = 0.09 and log2[10 years/6 years]: –0.1) (Figure 3B).