The 75 T2D-associated proteins from either of the cross-sectional analyses (Supplemental Data File 1) included established T2D signatures previously reported, such as insulin-like growth factor-binding protein 2 (IGFBP2) or sex hormone-binding globulin (SHBG), but also included relatively new T2D-associations with proteins such as heparan sulfate proteoglycan 2 (HSPG2). Here, SHBG is linked to type 2 diabetes mellitus.