Finally, we observed support for PON3, APOD, IL1RAP, VTN, VCAM1, and IGFBP2 genes/proteins associated with T2D (top 5% in a framework) using an orthogonal and comprehensive ML framework (49–51), leveraging thousands of publicly available annotation data, including UK Biobank’s health record data. The gene discussed is PON3; the disease is type 2 diabetes mellitus.