Intrathecal administration of AAV9/hSLC6A1 to P5 mice rescues abnormal EEG patterns in heterozygous Slc6a1+/– mice and nest-building behavior in homozygous Slc6a1–/– KO mice, but fails to rescue brain EEG epilepsy in Slc6a1–/– KO mice. The gene discussed is SLC6A1; the disease is epilepsy.