GZMB and neoplasm: While these cells exhibit slightly reduced cytotoxicity against tumor cells, they do not show a significant decline in the production of critical effector cytokines such as IFN-γ, TNF-α, and granzyme B. This suggests that ITK deficiency primarily affects the immediate cytotoxic effects of CAR-T cells, which may not be as critical for long-term antitumor responses.