Previous studies have shown that dysfunction of the Hippo pathway is associated with the development and metastasis of CRC.53,54 However, the expression of CYP1A2 and CYP2A6 was significantly increased in 5-fluorouracil- and oxaliplatin-resistant cells.55 Silencing of E-cadherin expression increases the chemosensitivity of CRC cell lines to irinotecan and oxaliplatin.56 Further studies are needed to confirm the mechanism of oxaliplatin resistance in CRC. This evidence concerns the gene CDH1 and colorectal carcinoma.