INS and Insulin resistance: Consistent with these findings, upregulation of Traf3 led to restoration of glucose intolerance (Figure 5O) and insulin resistance (Figure 5—figure supplement 1J) after 16 weeks of Traf3 eWAT treatment in HFD-fed Mir802 KI mice, coupled with a decrease in fasting insulin levels (Figure 5—figure supplement 1K) and ameliorative HOMA-IR (Figure 5P).