Interestingly, SCF is expressed in the dorsal aorta at E9.5-E11.5 (Rybtsov et al., 2014, 2011; Taoudi et al., 2008) and Scf−/− mice die in utero as a result of severe anemia and lack HSCs (Broudy, 1997; Ding et al., 2012). The gene discussed is KITLG; the disease is anemia.