Upregulation of Nr4a gene expression in VE-cadherin+CD45+ HE relative to the endothelium in the E11.5 AGM (Fig. 1) and the lack of engraftment potential in Nr4a1−/−Nr4a2−/− E11.5 embryos (Fig. 2) suggest that Nr4a genes may play a role in EHT. This evidence concerns the gene PTPRC and essential hypertension, genetic.