This double‐blind, randomized research led us to the conclusion that tacrolimus 0.03% ointment is superior to hydrocortisone cream in terms of reducing inflammatory markers such as TARC, CTACK, TSLP, and E‐selectin in children with AD; nevertheless, there was no difference in terms of the Children's Dermatology Life Quality Index. This evidence concerns the gene SELE and Alzheimer disease.